Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions
Electronic Archive of Sumy State University
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions
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| Creator |
Zheltonozhskaya, T.B.
Partsevskaya, S.V. Klymchuk, D.O. Gorchev, V.F. |
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| Subject |
Triblock copolymer
Intramolecular polycomplex Micelles Prednisolone Encapsulation |
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| Description |
Encapsulaton of poorly soluble crystallizing drug prednisolone (PS) in micellar solutions of PAAm-b- PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide (MnPEO = 6 kDa, MnPAAm = 116 kDa) was studied by dynamic light scattering and transmission electron microscopy. The equilibrium mechanism of the encapsulation process and the effect of specific aggregation of PS-loaded micelles by their “coronas” that promoted the drug crystallization were established. The question about the presence of TBC micelles inside crystalline space was discussed. |
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| Publisher |
Sumy State University
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| Date |
2014-05-28T06:40:47Z
2014-05-28T06:40:47Z 2013 |
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| Type |
Article
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| Identifier |
Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions [Текст] / T.B. Zheltonozhskaya, S.V. Partsevskaya, D.O. Klymchuk, V.F. Gorchev
// Nanomaterials: Applications & Properties (NAP-2013) : 3-rd International conference, Alushta, the Crimea, Ukraine, September 16-21, 2013 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2013. - V.2, No2. - 02PCN33
http://essuir.sumdu.edu.ua/handle/123456789/35235 |
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| Language |
en
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