Poly(lactic acid) scaffolds modified by gelatin for the controlled release of tetrandrine in vitro
Vernadsky National Library of Ukraine
Переглянути архів Інформація| Поле | Співвідношення | |
| Title |
Poly(lactic acid) scaffolds modified by gelatin for the controlled release of tetrandrine in vitro
|
|
| Creator |
Zhang Ye
|
|
| Subject |
Technology
|
|
| Description |
To mimic natural extracellular matrix architecture, tetrandrine-loaded poly(L-lactic acid) scaffolds modified by gelatin were prepared via phase separation, solvent replacement and freeze-drying. The purpose of this work was to combine the biological effects of tetrandrine and the advantages of poly(L-lactic acid) scaffolds which was modified by gelatin to enhancing the mass transfer features of controlled release systems. Tetrandrine contained in the scaffolds was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared (FT-IR) spectroscopy. Tetrandrine did not change the morphous, crystallinity and thermodynamics of the scaffolds which demonstrated by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray powder diffractometry (XRD). The results of this study showed a sustained release with 79.15% for 188 days in vitro.
|
|
| Date |
2018-06-16T17:23:41Z
2018-06-16T17:23:41Z 2017 |
|
| Type |
Article
|
|
| Identifier |
Poly(lactic acid) scaffolds modified by gelatin for the controlled release of tetrandrine in vitro / Zhang Ye // Functional Materials. — 2017. — Т. 24, № 4. — С. 660-666. — Бібліогр.: 34 назв. — англ.
1027-5495 DOI: https://doi.org/10.15407/fm24.04.660 http://dspace.nbuv.gov.ua/handle/123456789/136891 |
|
| Language |
en
|
|
| Relation |
Functional Materials
|
|
| Publisher |
НТК «Інститут монокристалів» НАН України
|
|